Isotyping antibodies produced from hybridoma A6G11C9
نویسندگان
چکیده
منابع مشابه
Bispecific Antibodies from Hybrid Hybridoma
Hybrid hybridomas (also termed quadromas or tetradomas) are man-made cell lines that secrete bispecific antibodies (bsAb) with two different specificities being able to crosslink two distinct molecules. Such antibodies do not occur in nature and have been originally developed to improve immunohistochemical staining procedures and immunoassays (Milstein and Cuello 1983; Suresh et al. 1986). Inte...
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Three major groups of antibodies have been identified during the analysis of the clonal response to phosphoeholine (PC). t The predominant one shows multiple molecular features of the PC-binding myeloma protein (PC-BMP) TEPC 15 (1-3), and two others possess idiotypes (Id) and L-chain characteristics of two other PCBMP, M511 (2, 4) and M603 (5). All three Id groups are conserved in inbred mice (...
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Three major groups of antibodies have been identified during the analysis of the clonal response to phosphoeholine (PC). t The predominant one shows multiple molecular features of the PC-binding myeloma protein (PC-BMP) TEPC 15 (1-3), and two others possess idiotypes (Id) and L-chain characteristics of two other PCBMP, M511 (2, 4) and M603 (5). All three Id groups are conserved in inbred mice (...
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Hybridomas are cells that have been engineered to produce a desired antibody in large amounts. To produce monoclonal antibodies, Bcells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B-cells are then fused with myeloma tumor cells that can grow indefinitely in culture (myeloma is a B-cell cancer). This fusion is performed by making the cell me...
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Hybridoma cells which secrete colorectal carcinoma-specific antibodies have been produced and used to study the antigenic structure of these tumor cells. Nineteen antibodies have been studied in detail, and 15 of these are colorectal carcinoma specific. Only two antibodies reactive with carcinoembryonic antigen (CEA) have been discovered and five other antibodies that react with distinct epitop...
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ژورنال
عنوان ژورنال: Vietnam Journal of Biotechnology
سال: 2018
ISSN: 1811-4989,1811-4989
DOI: 10.15625/1811-4989/15/1/12318